|
KMID : 0613820170270040383
|
|
Journal of Life Science
2017 Volume.27 No. 4 p.383 ~ p.389
|
|
|
Photoprotective Effect of Grape Pruning Stem Extracts on the UVB Induced HR-1 Mice Skin
|
|
Kim Joung-Hee
Kim Jong-Kuk
Kim Sun-Gun
Jeong Seung-Il
Jang Min-Jung
Kim Kil-Soo
Kim Keuk-Jun
Kwack Seung-Jun
|
|
|
Abstract
|
|
|
|
This study intends to analyze the contents of rutin, procyanidin B3, quercetin, kaempferol, known to have antioxidant, anti-inflammatory and anti-carcinogenic effects, among the polyphenol type contained in the grape pruning stem extracts (GPSE), utilizing grape stems being discarded after harvest, measure the effects on the skin moisture, inhibition of skin cell proliferation, anti-inflammatory on the damaged skin of a HR-1 mice induced with UVB, and verify the applicability as a material for functional food and functional cosmetics. The results of verifying the photoprotection effects through the skin proliferation control through of GPSE showed similar result to suncream was achieved at the GPSE concentration of 2,000 mg/kg on the epidermis (p<0.05). The results showed anti-inflammatory effects on all groups applied with GPSE as compared to the control group irradiated with UVB, but at the GPSE concentration of 1,000 mg/kg, a lower COX-2 protein expression at 8%, lower than the 22% of suncream, was observed to achieve an excellent anti-inflammatory effect (p<0.05). The results of this study confirmed the existence of active polyphenol type, such as rutin, kaempferol, querocetin and procyanidin B3, within the GPSE, and GPSE has improvement effects on moisturizing effects, skin proliferation control effect, inflammatory control effect and improvement effects on the skin barrier function through UV ray damage. GPSE is a functional ingredient with a potential for skin protection effects, and has high utilization as an ingredient for functional food and functional cosmetics.
|
|
|
KEYWORD
|
|
|
Grape pruning stem, photoprotective effect, polyphenol, skin barrier, UVB
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|